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Assay Detail

CHEMBL813360

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Binding
In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductase
ChEMBL ↗
71
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Steroid 5-alpha-reductase (CHEMBL2096664) ↗
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding.
Rasmusson GH, Reynolds GF, Steinberg NG, Walton E, Patel GF, Liang T, Cascieri MA, Cheung AH, Brooks JR, Berman C.
J Med Chem (1986) 29 : 2298 -2315
PubMed 3783591 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 71 7.58 9.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3349118 — — 1 9.89
CHEMBL3349105 — — 1 9.68
CHEMBL3349170 — — 1 9.25
CHEMBL3349075 — — 1 8.92
CHEMBL1790294 — — 1 8.77
CHEMBL3349144 — — 1 8.72
CHEMBL3349288 — — 1 8.60
CHEMBL3349113 — — 1 8.55
CHEMBL3349082 — — 1 8.47
CHEMBL1790287 — — 1 8.47
CHEMBL2021336 — — 1 8.46
CHEMBL1790293 — — 1 8.44
CHEMBL1790279 — — 1 8.42
CHEMBL3349167 — — 1 8.34
CHEMBL3349147 — — 1 8.34
CHEMBL3349168 — — 1 8.20
CHEMBL2298410 — — 1 8.17
CHEMBL710 FINASTERIDE 4.0 1 8.17
CHEMBL3349141 — — 1 8.12
CHEMBL1790284 — — 1 8.12
CHEMBL3349116 — — 1 8.12
CHEMBL3085570 — — 1 8.10
CHEMBL3349139 — — 1 7.96
CHEMBL2298601 — — 1 7.96
CHEMBL3349111 — — 1 7.92
CHEMBL1790288 — — 1 7.89
CHEMBL3349160 — — 1 7.89
CHEMBL3349083 — — 1 7.89
CHEMBL3349142 — — 1 7.80
CHEMBL3349104 — — 1 7.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3349118 — IC50 = 0.13 nM 9.89
CHEMBL3349105 — IC50 = 0.21 nM 9.68
CHEMBL3349170 — IC50 = 0.56 nM 9.25
CHEMBL3349075 — IC50 = 1.2 nM 8.92
CHEMBL1790294 — IC50 = 1.7 nM 8.77
CHEMBL3349144 — IC50 = 1.9 nM 8.72
CHEMBL3349288 — IC50 = 2.5 nM 8.60
CHEMBL3349113 — IC50 = 2.8 nM 8.55
CHEMBL3349082 — IC50 = 3.4 nM 8.47
CHEMBL1790287 — IC50 = 3.4 nM 8.47
CHEMBL2021336 — IC50 = 3.5 nM 8.46
CHEMBL1790293 — IC50 = 3.6 nM 8.44
CHEMBL1790279 — IC50 = 3.8 nM 8.42
CHEMBL3349167 — IC50 = 4.6 nM 8.34
CHEMBL3349147 — IC50 = 4.6 nM 8.34
CHEMBL3349168 — IC50 = 6.3 nM 8.20
CHEMBL2298410 — IC50 = 6.8 nM 8.17
CHEMBL710 FINASTERIDE IC50 = 6.8 nM 8.17
CHEMBL3349141 — IC50 = 7.6 nM 8.12
CHEMBL1790284 — IC50 = 7.6 nM 8.12
CHEMBL3349116 — IC50 = 7.6 nM 8.12
CHEMBL3085570 — IC50 = 7.9 nM 8.10
CHEMBL3349139 — IC50 = 11.0 nM 7.96
CHEMBL2298601 — IC50 = 11.0 nM 7.96
CHEMBL3349111 — IC50 = 12.0 nM 7.92
CHEMBL1790288 — IC50 = 13.0 nM 7.89
CHEMBL3349083 — IC50 = 13.0 nM 7.89
CHEMBL3349160 — IC50 = 13.0 nM 7.89
CHEMBL3349142 — IC50 = 16.0 nM 7.80
CHEMBL3349104 — IC50 = 17.0 nM 7.77
CHEMBL2298402 — IC50 = 20.0 nM 7.70
CHEMBL2295868 — IC50 = 20.0 nM 7.70
CHEMBL3349088 — IC50 = 20.0 nM 7.70
CHEMBL3349073 — IC50 = 22.0 nM 7.66
CHEMBL3349128 — IC50 = 25.0 nM 7.60
CHEMBL3349145 — IC50 = 27.0 nM 7.57
CHEMBL3349138 — IC50 = 33.0 nM 7.48
CHEMBL3349510 — IC50 = 36.0 nM 7.44
CHEMBL3349293 — IC50 = 37.0 nM 7.43
CHEMBL3085568 — IC50 = 37.0 nM 7.43
CHEMBL3349112 — IC50 = 38.0 nM 7.42
CHEMBL3349114 — IC50 = 40.0 nM 7.40
CHEMBL3349181 — IC50 = 41.0 nM 7.39
CHEMBL3349151 — IC50 = 50.0 nM 7.30
CHEMBL3349292 — IC50 = 58.0 nM 7.24
CHEMBL3349158 — IC50 = 79.0 nM 7.10
CHEMBL2298401 — IC50 = 86.0 nM 7.07
CHEMBL573180 — IC50 = 86.0 nM 7.07
CHEMBL3349290 — IC50 = 93.0 nM 7.03
CHEMBL3349090 — IC50 = 93.0 nM 7.03