Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL813430

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against thrombin
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.
Wendt MD, Geyer A, McClellan WJ, Rockway TW, Weitzberg M, Zhao X, Mantei R, Stewart K, Nienaber V, Klinghofer V, Giranda VL.
Bioorg Med Chem Lett (2004) 14 : 3063 -3068
PubMed 15149645 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.08 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL104211 1 6.92
CHEMBL319047 1 6.89
CHEMBL104505 1 6.77
CHEMBL321319 1 6.54
CHEMBL105395 1 6.44
CHEMBL320817 1 6.35
CHEMBL320233 1 6.21
CHEMBL104166 1 6.03
CHEMBL421214 1 5.96
CHEMBL104904 1 5.89
CHEMBL103043 1 5.50
CHEMBL319264 1 5.28
CHEMBL104937 1 5.25
CHEMBL321944 1 5.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL104211 Ki = 120.0 nM 6.92
CHEMBL319047 Ki = 130.0 nM 6.89
CHEMBL104505 Ki = 170.0 nM 6.77
CHEMBL321319 Ki = 290.0 nM 6.54
CHEMBL105395 Ki = 360.0 nM 6.44
CHEMBL320817 Ki = 450.0 nM 6.35
CHEMBL320233 Ki = 610.0 nM 6.21
CHEMBL104166 Ki = 940.0 nM 6.03
CHEMBL421214 Ki = 1100.0 nM 5.96
CHEMBL104904 Ki = 1300.0 nM 5.89
CHEMBL103043 Ki = 3200.0 nM 5.50
CHEMBL319264 Ki = 5200.0 nM 5.28
CHEMBL104937 Ki = 5600.0 nM 5.25
CHEMBL321944 Ki = 7100.0 nM 5.15