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Assay Detail

CHEMBL813435

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of thrombin.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

4-amidinobenzylamine-based inhibitors of urokinase.
Künzel S, Schweinitz A, Reissmann S, Stürzebecher J, Steinmetzer T.
Bioorg Med Chem Lett (2002) 12 : 645 -648
PubMed 11844691 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 5.46 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL158939 1 7.92
CHEMBL433510 1 7.30
CHEMBL158405 1 6.96
CHEMBL159162 1 5.52
CHEMBL345435 1 5.40
CHEMBL158814 1 5.00
CHEMBL346117 1 4.96
CHEMBL158936 1 4.89
CHEMBL352009 1 4.82
CHEMBL157131 1 4.82
CHEMBL156858 1 4.80
CHEMBL415741 1 4.48
CHEMBL350657 1 4.16
CHEMBL349545 1 -
CHEMBL160944 1 -
CHEMBL2371217 1 -
CHEMBL160580 1 -
CHEMBL422533 1 -
CHEMBL157479 1 -
CHEMBL440919 1 -
CHEMBL345236 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL158939 Ki = 12.0 nM 7.92
CHEMBL433510 Ki = 50.0 nM 7.30
CHEMBL158405 Ki = 110.0 nM 6.96
CHEMBL159162 Ki = 3000.0 nM 5.52
CHEMBL345435 Ki = 4000.0 nM 5.40
CHEMBL158814 Ki = 10000.0 nM 5.00
CHEMBL346117 Ki = 11000.0 nM 4.96
CHEMBL158936 Ki = 13000.0 nM 4.89
CHEMBL352009 Ki = 15000.0 nM 4.82
CHEMBL157131 Ki = 15000.0 nM 4.82
CHEMBL156858 Ki = 16000.0 nM 4.80
CHEMBL415741 Ki = 33000.0 nM 4.48
CHEMBL350657 Ki = 69000.0 nM 4.16
CHEMBL349545 Ki > 1000000.0 nM -
CHEMBL160944 Ki = 200000.0 nM -
CHEMBL2371217 Ki > 1000000.0 nM -
CHEMBL160580 Ki > 1000000.0 nM -
CHEMBL422533 Ki = 230000.0 nM -
CHEMBL157479 Ki > 1000000.0 nM -
CHEMBL440919 Ki = 170000.0 nM -
CHEMBL345236 Ki > 1000000.0 nM -