Assay Detail
Binding
CHEMBL813550
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Inhibitory activity was evaluated against the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | mushroom |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-hydroxy-4-isopropylbenzaldehyde, a potent partial tyrosinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.82 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353354 | CHAMAECIN | — | 1 | 5.64 |
| CHEMBL350966 | — | — | 1 | 4.52 |
| CHEMBL161577 | CUMINALDEHYDE | — | 1 | 4.30 |
| CHEMBL161598 | ANISALDEHYDE | — | 1 | - |
| CHEMBL108925 | SALICYLADEHYDE | — | 1 | - |
| CHEMBL15972 | BENZALDEHYDE | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353354 | CHAMAECIN | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL350966 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL161577 | CUMINALDEHYDE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL161598 | ANISALDEHYDE | IC50 | = | 320000.0 | nM | - |
| CHEMBL108925 | SALICYLADEHYDE | IC50 | = | 3300000.0 | nM | - |
| CHEMBL15972 | BENZALDEHYDE | IC50 | = | 820000.0 | nM | - |