Assay Detail
Functional
CHEMBL813558
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Glucocorticoid induced transactivation of human tyrosine amino transferase in HepG2 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.66 | 7.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310570 | — | — | 1 | 7.45 |
| CHEMBL311662 | — | — | 1 | 7.24 |
| CHEMBL312041 | — | — | 1 | 7.08 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 6.68 |
| CHEMBL79335 | — | — | 1 | 6.59 |
| CHEMBL312399 | — | — | 1 | 6.48 |
| CHEMBL313062 | — | — | 1 | 6.28 |
| CHEMBL309243 | — | — | 1 | 6.18 |
| CHEMBL82546 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310570 | — | EC50 | = | 35.6 | nM | 7.45 |
| CHEMBL311662 | — | EC50 | = | 57.2 | nM | 7.24 |
| CHEMBL312041 | — | EC50 | = | 83.5 | nM | 7.08 |
| CHEMBL131 | PREDNISOLONE | EC50 | = | 211.0 | nM | 6.68 |
| CHEMBL79335 | — | EC50 | = | 255.7 | nM | 6.59 |
| CHEMBL312399 | — | EC50 | = | 332.0 | nM | 6.48 |
| CHEMBL313062 | — | EC50 | = | 520.8 | nM | 6.28 |
| CHEMBL309243 | — | EC50 | = | 660.9 | nM | 6.18 |
| CHEMBL82546 | — | EC50 | = | 1004.0 | nM | 6.00 |