Assay Detail
Binding
CHEMBL813565
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Compound was evaluated for its inhibitory activity against human thrombin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification and SAR for a selective, nonpeptidyl thrombin inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.09 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48016 | — | — | 1 | 7.24 |
| CHEMBL47481 | — | — | 1 | 6.80 |
| CHEMBL47543 | — | — | 1 | 6.16 |
| CHEMBL47486 | — | — | 1 | 5.89 |
| CHEMBL47751 | — | — | 1 | 5.33 |
| CHEMBL48029 | — | — | 1 | 5.10 |
| CHEMBL47349 | — | — | 1 | - |
| CHEMBL296280 | — | — | 1 | - |
| CHEMBL45648 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48016 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL47481 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL47543 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL47486 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL47751 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL48029 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL47349 | — | Ki | = | 581000.0 | nM | - |
| CHEMBL296280 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL45648 | — | Ki | > | 10000.0 | nM | - |