Assay Detail
Binding
CHEMBL813568
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against human alpha thrombin.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.05 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320749 | — | — | 1 | 5.63 |
| CHEMBL111471 | — | — | 1 | 5.46 |
| CHEMBL109367 | — | — | 1 | 5.30 |
| CHEMBL323387 | — | — | 1 | 5.28 |
| CHEMBL111575 | — | — | 1 | 5.25 |
| CHEMBL104937 | — | — | 1 | 5.25 |
| CHEMBL442201 | — | — | 1 | 5.24 |
| CHEMBL108447 | — | — | 1 | 5.19 |
| CHEMBL111567 | — | — | 1 | 5.16 |
| CHEMBL109535 | — | — | 1 | 5.14 |
| CHEMBL111338 | — | — | 1 | 4.99 |
| CHEMBL109287 | — | — | 1 | 4.75 |
| CHEMBL418839 | — | — | 1 | 4.67 |
| CHEMBL111543 | — | — | 1 | 4.66 |
| CHEMBL111432 | — | — | 1 | 4.46 |
| CHEMBL111660 | — | — | 1 | 4.36 |
| CHEMBL324168 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320749 | — | Ki | = | 2350.0 | nM | 5.63 |
| CHEMBL111471 | — | Ki | = | 3490.0 | nM | 5.46 |
| CHEMBL109367 | — | Ki | = | 4990.0 | nM | 5.30 |
| CHEMBL323387 | — | Ki | = | 5310.0 | nM | 5.28 |
| CHEMBL111575 | — | Ki | = | 5580.0 | nM | 5.25 |
| CHEMBL104937 | — | Ki | = | 5640.0 | nM | 5.25 |
| CHEMBL442201 | — | Ki | = | 5720.0 | nM | 5.24 |
| CHEMBL108447 | — | Ki | = | 6440.0 | nM | 5.19 |
| CHEMBL111567 | — | Ki | = | 6920.0 | nM | 5.16 |
| CHEMBL109535 | — | Ki | = | 7310.0 | nM | 5.14 |
| CHEMBL111338 | — | Ki | = | 10160.0 | nM | 4.99 |
| CHEMBL109287 | — | Ki | = | 17600.0 | nM | 4.75 |
| CHEMBL418839 | — | Ki | = | 21600.0 | nM | 4.67 |
| CHEMBL111543 | — | Ki | = | 21700.0 | nM | 4.66 |
| CHEMBL111432 | — | Ki | = | 35100.0 | nM | 4.46 |
| CHEMBL111660 | — | Ki | = | 43700.0 | nM | 4.36 |
| CHEMBL324168 | — | Ki | > | 100000.0 | nM | - |