Assay Detail
Binding
CHEMBL813569
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Binding affinity against human thrombin
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 8.87 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159688 | — | — | 1 | 10.82 |
| CHEMBL7860 | — | — | 1 | 10.70 |
| CHEMBL1159694 | — | — | 1 | 10.44 |
| CHEMBL1159692 | — | — | 1 | 10.44 |
| CHEMBL1159690 | — | — | 1 | 10.36 |
| CHEMBL1159689 | — | — | 1 | 10.35 |
| CHEMBL268640 | — | — | 1 | 10.30 |
| CHEMBL1159691 | — | — | 1 | 10.00 |
| CHEMBL1159693 | — | — | 1 | 9.80 |
| CHEMBL7962 | — | — | 1 | 9.42 |
| CHEMBL451242 | — | — | 1 | 9.30 |
| CHEMBL7440 | — | — | 1 | 9.28 |
| CHEMBL266349 | MELAGATRAN | 4.0 | 1 | 8.92 |
| CHEMBL7292 | — | — | 1 | 8.74 |
| CHEMBL414606 | — | — | 1 | 8.66 |
| CHEMBL268833 | — | — | 1 | 8.62 |
| CHEMBL7865 | — | — | 1 | 8.40 |
| CHEMBL8079 | — | — | 1 | 8.28 |
| CHEMBL268824 | — | — | 1 | 8.24 |
| CHEMBL7418 | — | — | 1 | 8.22 |
| CHEMBL7656 | — | — | 1 | 8.17 |
| CHEMBL415298 | — | — | 1 | 7.92 |
| CHEMBL7197 | — | — | 1 | 7.85 |
| CHEMBL266196 | — | — | 1 | 7.74 |
| CHEMBL267502 | — | — | 1 | 7.51 |
| CHEMBL7213 | — | — | 1 | 7.50 |
| CHEMBL8133 | — | — | 1 | 7.33 |
| CHEMBL407992 | — | — | 1 | 7.08 |
| CHEMBL266040 | — | — | 1 | 6.98 |
| CHEMBL1159685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159688 | — | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL7860 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL1159694 | — | Ki | = | 0.036 | nM | 10.44 |
| CHEMBL1159692 | — | Ki | = | 0.036 | nM | 10.44 |
| CHEMBL1159690 | — | Ki | = | 0.044 | nM | 10.36 |
| CHEMBL1159689 | — | Ki | = | 0.045 | nM | 10.35 |
| CHEMBL268640 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL1159691 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL1159693 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL7962 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL451242 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL7440 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL266349 | MELAGATRAN | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL7292 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL414606 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL268833 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL7865 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL8079 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL268824 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL7418 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL7656 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL415298 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL7197 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL266196 | — | Ki | = | 18.3 | nM | 7.74 |
| CHEMBL267502 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL7213 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL8133 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL407992 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL266040 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL1159685 | — | Ki | = | 0.003 | nM | - |
| CHEMBL7895 | — | Ki | = | 0.005 | nM | - |
| CHEMBL1159687 | — | Ki | = | 0.003 | nM | - |
| CHEMBL269575 | — | Ki | = | 0.003 | nM | - |
| CHEMBL1159686 | — | Ki | = | 0.005 | nM | - |