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Assay Detail

CHEMBL813618

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Binding
Inhibitory constant against thrombin using human purified enzymes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Nonbenzamidine tetrazole derivatives as factor Xa inhibitors.
Quan ML, Ellis CD, He MY, Liauw AY, Woerner FJ, Alexander RS, Knabb RM, Lam PY, Luettgen JM, Wong PC, Wright MR, Wexler RR.
Bioorg Med Chem Lett (2003) 13 : 369 -373
PubMed 12565931 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 5.80 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL332157 1 6.52
CHEMBL441283 1 6.40
CHEMBL333270 1 6.22
CHEMBL122902 1 5.92
CHEMBL442766 1 5.82
CHEMBL333806 1 5.80
CHEMBL123272 1 5.80
CHEMBL122456 1 5.40
CHEMBL124834 1 5.10
CHEMBL340577 1 5.00
CHEMBL122796 1 -
CHEMBL123033 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL332157 Ki = 300.0 nM 6.52
CHEMBL441283 Ki = 400.0 nM 6.40
CHEMBL333270 Ki = 600.0 nM 6.22
CHEMBL122902 Ki = 1200.0 nM 5.92
CHEMBL442766 Ki = 1500.0 nM 5.82
CHEMBL333806 Ki = 1600.0 nM 5.80
CHEMBL123272 Ki = 1600.0 nM 5.80
CHEMBL122456 Ki = 4000.0 nM 5.40
CHEMBL124834 Ki = 7900.0 nM 5.10
CHEMBL340577 Ki = 10000.0 nM 5.00
CHEMBL122796 Ki > 21000.0 nM -
CHEMBL123033 Ki > 21000.0 nM -