Assay Detail
Binding
CHEMBL813621
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Inhibitory constant against human thrombin was determined in vitro.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Fluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.25 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312244 | — | — | 1 | 10.22 |
| CHEMBL82057 | — | — | 1 | 10.00 |
| CHEMBL79304 | — | — | 1 | 9.70 |
| CHEMBL7962 | — | — | 1 | 9.40 |
| CHEMBL84454 | — | — | 1 | 9.30 |
| CHEMBL313296 | — | — | 1 | 9.15 |
| CHEMBL314189 | — | — | 1 | 9.05 |
| CHEMBL312011 | — | — | 1 | 8.74 |
| CHEMBL82072 | — | — | 1 | 8.70 |
| CHEMBL83205 | — | — | 1 | 8.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312244 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL82057 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL79304 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL7962 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL84454 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL313296 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL314189 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL312011 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL82072 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL83205 | — | Ki | = | 5.5 | nM | 8.26 |