Assay Detail
Binding
CHEMBL813625
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of human thrombin.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.16 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81056 | — | — | 1 | 9.43 |
| CHEMBL84389 | — | — | 1 | 9.28 |
| CHEMBL84229 | — | — | 1 | 9.10 |
| CHEMBL309670 | — | — | 1 | 9.02 |
| CHEMBL309403 | — | — | 1 | 8.96 |
| CHEMBL82658 | — | — | 1 | 8.89 |
| CHEMBL312647 | — | — | 1 | 8.74 |
| CHEMBL81521 | — | — | 1 | 8.66 |
| CHEMBL82535 | — | — | 1 | 8.15 |
| CHEMBL418923 | — | — | 1 | 8.01 |
| CHEMBL312661 | — | — | 1 | 7.82 |
| CHEMBL81436 | — | — | 1 | 7.80 |
| CHEMBL83280 | — | — | 1 | 7.80 |
| CHEMBL81251 | — | — | 1 | 7.50 |
| CHEMBL313788 | — | — | 1 | 7.25 |
| CHEMBL79442 | — | — | 1 | 7.05 |
| CHEMBL81844 | — | — | 1 | 6.92 |
| CHEMBL81643 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81056 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL84389 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL84229 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL309670 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL309403 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL82658 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL312647 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL81521 | — | Ki | = | 2.17 | nM | 8.66 |
| CHEMBL82535 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL418923 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL312661 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL81436 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL83280 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL81251 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL313788 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL79442 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL81844 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL81643 | — | Ki | = | 370.0 | nM | 6.43 |