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Assay Detail

CHEMBL813631

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Binding
Tested for the binding affinity against thrombin
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis and biological activity of novel non-amidine factor Xa inhibitors. Part 1: P(1) structure-activity relationships of the substituted 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides.
Jia ZJ, Wu Y, Huang W, Goldman E, Zhang P, Woolfrey J, Wong P, Huang B, Sinha U, Park G, Reed A, Scarborough RM, Zhu BY.
Bioorg Med Chem Lett (2002) 12 : 1651 -1655
PubMed 12039583 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.52 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37251 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37251 Ki = 300.0 nM 6.52