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Assay Detail

CHEMBL813632

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Binding
Tested for the binding affinity against thrombin
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

S1 heterocyclic thrombin inhibitors
Dominguez C, Carini D, Weber P, Knabb R, Alexander R, Kettner C, Wexler R
Bioorg Med Chem Lett (1997) 7 : 79 -84
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 7.36 10.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL607008 1 10.40
CHEMBL353712 1 8.77
CHEMBL606951 1 8.68
CHEMBL606954 1 8.49
CHEMBL606953 1 8.06
CHEMBL606958 1 7.82
CHEMBL606949 1 7.37
CHEMBL606957 1 7.17
CHEMBL606950 1 6.82
CHEMBL606955 1 6.70
CHEMBL607013 1 6.64
CHEMBL607009 1 6.46
CHEMBL606956 1 6.29
CHEMBL607012 1 6.22
CHEMBL606961 1 6.19
CHEMBL606952 1 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL607008 Ki = 0.04 nM 10.40
CHEMBL353712 Ki = 1.7 nM 8.77
CHEMBL606951 Ki = 2.1 nM 8.68
CHEMBL606954 Ki = 3.2 nM 8.49
CHEMBL606953 Ki = 8.8 nM 8.06
CHEMBL606958 Ki = 15.0 nM 7.82
CHEMBL606949 Ki = 43.0 nM 7.37
CHEMBL606957 Ki = 67.0 nM 7.17
CHEMBL606950 Ki = 150.0 nM 6.82
CHEMBL606955 Ki = 199.0 nM 6.70
CHEMBL607013 Ki = 230.0 nM 6.64
CHEMBL607009 Ki = 350.0 nM 6.46
CHEMBL606956 Ki = 507.0 nM 6.29
CHEMBL607012 Ki = 600.0 nM 6.22
CHEMBL606961 Ki = 650.0 nM 6.19
CHEMBL606952 Ki = 2000.0 nM 5.70