Assay Detail
Binding
CHEMBL813633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro for inhibition of human thrombin
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 5.40 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37251 | — | — | 1 | 6.52 |
| CHEMBL348441 | — | — | 1 | 5.85 |
| CHEMBL146910 | — | — | 1 | 5.82 |
| CHEMBL151939 | — | — | 1 | 5.44 |
| CHEMBL148944 | — | — | 1 | 5.39 |
| CHEMBL559015 | — | — | 1 | 5.22 |
| CHEMBL134736 | — | — | 1 | 5.22 |
| CHEMBL148718 | — | — | 1 | 5.19 |
| CHEMBL151201 | — | — | 1 | 5.04 |
| CHEMBL151627 | — | — | 1 | 4.85 |
| CHEMBL151750 | — | — | 1 | 4.82 |
| CHEMBL358604 | — | — | 1 | - |
| CHEMBL355992 | — | — | 1 | - |
| CHEMBL434659 | — | — | 1 | - |
| CHEMBL151522 | — | — | 1 | - |
| CHEMBL139121 | — | — | 1 | - |
| CHEMBL345731 | — | — | 1 | - |
| CHEMBL147171 | — | — | 1 | - |
| CHEMBL151122 | — | — | 1 | - |
| CHEMBL146982 | — | — | 1 | - |
| CHEMBL149583 | — | — | 1 | - |
| CHEMBL358488 | — | — | 1 | - |
| CHEMBL356261 | — | — | 1 | - |
| CHEMBL151629 | — | — | 1 | - |
| CHEMBL146793 | — | — | 1 | - |
| CHEMBL139788 | — | — | 1 | - |
| CHEMBL357739 | — | — | 1 | - |
| CHEMBL423759 | — | — | 1 | - |
| CHEMBL343472 | — | — | 1 | - |
| CHEMBL147132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37251 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL348441 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL146910 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL151939 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL148944 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL559015 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL134736 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL148718 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL151201 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL151627 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL151750 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL359449 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL149260 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL358604 | — | Ki | > | 13000.0 | nM | - |
| CHEMBL355992 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL434659 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL151522 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL139121 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL345731 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL147171 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL151122 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL146982 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL149583 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL358488 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL356261 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL151629 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL146793 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL139788 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL357739 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL423759 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL343472 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL147132 | — | Ki | > | 21000.0 | nM | - |