Assay Detail
Binding
CHEMBL813634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The binding affinity towards thrombin obtained from human purified enzymes.
28
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 5.64 | 10.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1202108 | — | — | 1 | 10.35 |
| CHEMBL72514 | — | — | 1 | 6.22 |
| CHEMBL93227 | — | — | 1 | 5.92 |
| CHEMBL93536 | — | — | 1 | 5.92 |
| CHEMBL319206 | — | — | 1 | 5.85 |
| CHEMBL92519 | — | — | 1 | 5.75 |
| CHEMBL329568 | — | — | 1 | 5.68 |
| CHEMBL264628 | — | — | 1 | 5.68 |
| CHEMBL279628 | — | — | 4 | 5.62 |
| CHEMBL316349 | — | — | 1 | 5.57 |
| CHEMBL327430 | — | — | 1 | 5.55 |
| CHEMBL327404 | — | — | 4 | 5.54 |
| CHEMBL433369 | — | — | 1 | 5.51 |
| CHEMBL328239 | — | — | 1 | 5.51 |
| CHEMBL91796 | — | — | 1 | 5.46 |
| CHEMBL408928 | — | — | 1 | 5.42 |
| CHEMBL327213 | — | — | 4 | 5.05 |
| CHEMBL321314 | — | — | 1 | 4.97 |
| CHEMBL92988 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1202108 | — | Ki | = | 0.045 | nM | 10.35 |
| CHEMBL72514 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL93536 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL93227 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL319206 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL92519 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL329568 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL264628 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL279628 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL316349 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL327430 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL327404 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL279628 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL328239 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL433369 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL279628 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL91796 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL408928 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL327404 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL327404 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL327213 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL321314 | — | Ki | = | 10800.0 | nM | 4.97 |
| CHEMBL327213 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL327213 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL92988 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL327404 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL327213 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL279628 | — | Ki | > | 21000.0 | nM | - |