Assay Detail
Binding
CHEMBL813635
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Binding affinity towards thrombin obtained from human purified enzymes
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 5.59 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264626 | — | — | 1 | 7.16 |
| CHEMBL321530 | — | — | 1 | 7.00 |
| CHEMBL323309 | — | — | 1 | 6.52 |
| CHEMBL329460 | — | — | 1 | 6.52 |
| CHEMBL159418 | — | — | 1 | 6.40 |
| CHEMBL323310 | — | — | 1 | 6.30 |
| CHEMBL7651 | — | — | 1 | 6.05 |
| CHEMBL328069 | — | — | 1 | 6.05 |
| CHEMBL93210 | — | — | 1 | 5.96 |
| CHEMBL316070 | — | — | 1 | 5.89 |
| CHEMBL406295 | — | — | 1 | 5.70 |
| CHEMBL1184021 | — | — | 1 | 5.68 |
| CHEMBL328298 | — | — | 1 | 5.62 |
| CHEMBL327201 | — | — | 1 | 5.55 |
| CHEMBL91999 | — | — | 1 | 5.54 |
| CHEMBL1183989 | — | — | 1 | 5.52 |
| CHEMBL279628 | — | — | 1 | 5.51 |
| CHEMBL328582 | — | — | 1 | 5.51 |
| CHEMBL436684 | — | — | 1 | 5.47 |
| CHEMBL328451 | — | — | 1 | 5.41 |
| CHEMBL327404 | — | — | 1 | 5.41 |
| CHEMBL92523 | — | — | 1 | 5.41 |
| CHEMBL330284 | — | — | 1 | 5.40 |
| CHEMBL327403 | — | — | 1 | 5.37 |
| CHEMBL94052 | — | — | 1 | 5.36 |
| CHEMBL327473 | — | — | 1 | 5.35 |
| CHEMBL1183796 | — | — | 1 | 5.30 |
| CHEMBL330496 | — | — | 1 | 5.24 |
| CHEMBL93744 | — | — | 1 | 5.24 |
| CHEMBL445678 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264626 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL321530 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL329460 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL323309 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL159418 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL323310 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL7651 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL328069 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL93210 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL316070 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL406295 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1184021 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL328298 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL327201 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL91999 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL1183989 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL279628 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL328582 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL436684 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL92523 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL327404 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL328451 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL330284 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL327403 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL94052 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL327473 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL1183796 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL330496 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL93744 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL445678 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL92909 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL327331 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL92609 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL318112 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL316311 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL328805 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL327213 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL327405 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL316318 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL328577 | — | Ki | > | 21000.0 | nM | - |