Assay Detail
Binding
CHEMBL813659
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Compound was tested for inhibition activity against human thrombin (FIIa)
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 5.43 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49958 | — | — | 1 | 6.44 |
| CHEMBL48233 | — | — | 1 | 6.28 |
| CHEMBL298415 | — | — | 1 | 6.26 |
| CHEMBL51824 | — | — | 1 | 5.92 |
| CHEMBL49786 | — | — | 1 | 5.85 |
| CHEMBL52205 | — | — | 1 | 5.72 |
| CHEMBL48691 | — | — | 1 | 5.60 |
| CHEMBL295263 | — | — | 1 | 5.47 |
| CHEMBL300622 | — | — | 1 | 5.47 |
| CHEMBL48409 | — | — | 1 | 5.38 |
| CHEMBL48199 | — | — | 1 | 5.31 |
| CHEMBL296532 | — | — | 1 | 5.22 |
| CHEMBL48827 | — | — | 1 | 4.96 |
| CHEMBL50127 | — | — | 1 | 4.85 |
| CHEMBL49636 | — | — | 1 | 4.66 |
| CHEMBL48604 | — | — | 1 | 4.57 |
| CHEMBL424036 | — | — | 1 | 4.43 |
| CHEMBL46077 | — | — | 1 | - |
| CHEMBL296618 | — | — | 1 | - |
| CHEMBL296530 | — | — | 1 | - |
| CHEMBL50714 | — | — | 1 | - |
| CHEMBL48864 | — | — | 1 | - |
| CHEMBL47264 | — | — | 1 | - |
| CHEMBL49295 | — | — | 1 | - |
| CHEMBL48206 | — | — | 1 | - |
| CHEMBL49358 | — | — | 1 | - |
| CHEMBL45785 | — | — | 1 | - |
| CHEMBL50961 | — | — | 1 | - |
| CHEMBL51482 | — | — | 1 | - |
| CHEMBL19902 | DX-9065A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49958 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL48233 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL298415 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL51824 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL49786 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL52205 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL48691 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL295263 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL300622 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL48409 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL48199 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL296532 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL48827 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL50127 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL49636 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL48604 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL424036 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL48595 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL45732 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL48965 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL50909 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL52479 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL48161 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL48497 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL19902 | DX-9065A | Ki | > | 5000.0 | nM | - |
| CHEMBL51482 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL50961 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL45785 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL49358 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL48206 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL49295 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL47264 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL48864 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL50714 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL296530 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL296618 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL46077 | — | Ki | > | 100000.0 | nM | - |