Assay Detail
Binding
CHEMBL813660
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Inhibition against human thrombin
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.56 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423259 | — | — | 1 | 9.52 |
| CHEMBL2373405 | — | — | 1 | 9.10 |
| CHEMBL317682 | — | — | 1 | 8.77 |
| CHEMBL2373403 | — | — | 1 | 8.74 |
| CHEMBL2373408 | — | — | 1 | 8.59 |
| CHEMBL2375178 | — | — | 1 | 8.46 |
| CHEMBL2373351 | — | — | 1 | 8.34 |
| CHEMBL2373367 | — | — | 1 | 8.26 |
| CHEMBL2373349 | — | — | 1 | 8.07 |
| CHEMBL2373344 | — | — | 1 | 8.06 |
| CHEMBL2373397 | — | — | 1 | 7.96 |
| CHEMBL2373342 | — | — | 1 | 7.51 |
| CHEMBL2373440 | — | — | 1 | 7.48 |
| CHEMBL2373399 | — | — | 1 | 7.48 |
| CHEMBL2373559 | — | — | 1 | 7.48 |
| CHEMBL2373558 | — | — | 1 | 7.44 |
| CHEMBL2373401 | — | — | 1 | 7.39 |
| CHEMBL2373475 | — | — | 1 | 7.33 |
| CHEMBL2373350 | — | — | 1 | 7.19 |
| CHEMBL2373402 | — | — | 1 | 7.14 |
| CHEMBL2373341 | — | — | 1 | 7.08 |
| CHEMBL2373555 | — | — | 1 | 7.07 |
| CHEMBL2373347 | — | — | 1 | 7.07 |
| CHEMBL2373348 | — | — | 1 | 6.82 |
| CHEMBL2373345 | — | — | 1 | 6.82 |
| CHEMBL2373346 | — | — | 1 | 6.80 |
| CHEMBL2373343 | — | — | 1 | 6.76 |
| CHEMBL2373302 | — | — | 1 | 6.68 |
| CHEMBL2373400 | — | — | 1 | 6.64 |
| CHEMBL2373352 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423259 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL2373405 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL317682 | — | Ki | = | 1.71 | nM | 8.77 |
| CHEMBL2373403 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL2373408 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL2375178 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL2373351 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL2373367 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL2373349 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL2373344 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL2373397 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2373342 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL2373440 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL2373399 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL2373559 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL2373558 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL2373401 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL2373475 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL2373350 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL2373402 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL2373341 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL2373555 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL2373347 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL2373348 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL2373345 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL2373346 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2373343 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL2373302 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL2373400 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL2373352 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL2373404 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL2373519 | — | Ki | > | 42.0 | nM | - |