Assay Detail
Binding
CHEMBL813664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against thrombin
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.07 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256394 | — | — | 1 | 7.62 |
| CHEMBL311198 | — | — | 1 | 7.52 |
| CHEMBL83549 | — | — | 1 | 7.40 |
| CHEMBL83681 | — | — | 1 | 7.37 |
| CHEMBL402843 | — | — | 1 | 7.19 |
| CHEMBL311947 | — | — | 1 | 7.12 |
| CHEMBL82060 | — | — | 1 | 7.01 |
| CHEMBL84461 | — | — | 1 | 6.98 |
| CHEMBL84127 | — | — | 1 | 6.85 |
| CHEMBL316383 | — | — | 1 | 6.78 |
| CHEMBL312887 | — | — | 1 | 6.70 |
| CHEMBL309931 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256394 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL311198 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL83549 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL83681 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL402843 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL311947 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL82060 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL84461 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL84127 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL316383 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL312887 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL309931 | — | Ki | = | 495.0 | nM | 6.30 |