Assay Detail
Binding
CHEMBL813672
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In vitro inhibitory activity against human thrombin(IIa)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.43 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421437 | — | — | 1 | 9.09 |
| CHEMBL123142 | — | — | 1 | 8.66 |
| CHEMBL121982 | — | — | 1 | 8.52 |
| CHEMBL122331 | — | — | 1 | 8.52 |
| CHEMBL337923 | — | — | 1 | 8.44 |
| CHEMBL123942 | — | — | 1 | 8.41 |
| CHEMBL125181 | — | — | 1 | 8.30 |
| CHEMBL122488 | — | — | 1 | 8.12 |
| CHEMBL122801 | — | — | 1 | 8.05 |
| CHEMBL122601 | — | — | 1 | 8.00 |
| CHEMBL338788 | — | — | 1 | 7.96 |
| CHEMBL96486 | — | — | 1 | 7.92 |
| CHEMBL331181 | — | — | 1 | 7.16 |
| CHEMBL123759 | — | — | 1 | 6.96 |
| CHEMBL331179 | — | — | 1 | 6.89 |
| CHEMBL122432 | — | — | 1 | 6.46 |
| CHEMBL420334 | — | — | 1 | 6.46 |
| CHEMBL435012 | — | — | 1 | 6.44 |
| CHEMBL124408 | — | — | 1 | 6.42 |
| CHEMBL331908 | — | — | 1 | 6.29 |
| CHEMBL421272 | — | — | 1 | 6.25 |
| CHEMBL121661 | — | — | 1 | 6.05 |
| CHEMBL331160 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421437 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL123142 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL121982 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL122331 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL337923 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL123942 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL125181 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL122488 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL122801 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL122601 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL338788 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL96486 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL331181 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL123759 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL331179 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL122432 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL420334 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL435012 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL124408 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL331908 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL421272 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL121661 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL331160 | — | Ki | = | 3700.0 | nM | 5.43 |