Assay Detail
Binding
CHEMBL813679
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Compound was tested for binding affinity against Mycobacterium tuberculosis thymidine monophosphate kinase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.58 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257695 | AZIDOTHYMIDINE MONOPHOSPHATE | — | 1 | 5.00 |
| CHEMBL1160604 | — | — | 1 | 4.72 |
| CHEMBL1160596 | — | — | 1 | 4.57 |
| CHEMBL1160603 | — | — | 1 | 4.37 |
| CHEMBL1160592 | — | — | 1 | 4.26 |
| CHEMBL1160597 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257695 | AZIDOTHYMIDINE MONOPHOSPHATE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1160604 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL1160596 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL1160603 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL1160592 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL1160597 | — | Ki | = | 235000.0 | nM | - |