Assay Detail
Functional
CHEMBL813700
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Evaluated for inhibitory concentration against UV-4 cells under aerobic conditions with a compound exposure of 1 h
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | UV-4 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.57 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543027 | — | — | 1 | 7.15 |
| CHEMBL538221 | — | — | 1 | 6.42 |
| CHEMBL278918 | — | — | 1 | 6.40 |
| CHEMBL17360 | — | — | 1 | 6.35 |
| CHEMBL19462 | — | — | 1 | 5.92 |
| CHEMBL19336 | — | — | 1 | 5.92 |
| CHEMBL273595 | — | — | 1 | 5.79 |
| CHEMBL19447 | — | — | 1 | 5.57 |
| CHEMBL282252 | — | — | 1 | 5.12 |
| CHEMBL17942 | — | — | 1 | 4.84 |
| CHEMBL19995 | — | — | 1 | 4.80 |
| CHEMBL19084 | — | — | 1 | 4.12 |
| CHEMBL281788 | — | — | 1 | 4.02 |
| CHEMBL19868 | — | — | 1 | - |
| CHEMBL274253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543027 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL538221 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL278918 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL17360 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL19462 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL19336 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL273595 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL19447 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL282252 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL17942 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL19995 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL19084 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL281788 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL19868 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL274253 | — | IC50 | = | 174000.0 | nM | - |