Assay Detail
Binding
CHEMBL813716
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Compound was tested for the ability to inhibit human platelets microsomal Thromboxane A2 synthase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Thromboxane modulating agents. 1. Design of 1-[(arylsulfonyl)amino] alkylindole derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.41 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105856 | — | — | 1 | 7.82 |
| CHEMBL102360 | — | — | 1 | 7.70 |
| CHEMBL103580 | — | — | 1 | 7.66 |
| CHEMBL46571 | — | — | 1 | 7.50 |
| CHEMBL432958 | — | — | 1 | 7.41 |
| CHEMBL321549 | — | — | 1 | 7.41 |
| CHEMBL320235 | — | — | 1 | 7.21 |
| CHEMBL102533 | — | — | 1 | 7.11 |
| CHEMBL102692 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105856 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL102360 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL103580 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL46571 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL432958 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL321549 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL320235 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL102533 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL102692 | — | IC50 | = | 135.0 | nM | 6.87 |