Assay Detail
Binding
CHEMBL813721
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.33 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21954 | — | — | 1 | 8.52 |
| CHEMBL282884 | — | — | 1 | 8.52 |
| CHEMBL416374 | — | — | 1 | 8.52 |
| CHEMBL21639 | — | — | 1 | 8.52 |
| CHEMBL21852 | — | — | 1 | 8.52 |
| CHEMBL21647 | — | — | 1 | 8.40 |
| CHEMBL277689 | SAMIXOGREL | 2.0 | 1 | 8.40 |
| CHEMBL21303 | — | — | 1 | 8.40 |
| CHEMBL281398 | TERBOGREL | 2.0 | 1 | 8.40 |
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 8.40 |
| CHEMBL21476 | — | — | 1 | 8.30 |
| CHEMBL22023 | — | — | 1 | 8.30 |
| CHEMBL21478 | — | — | 1 | 8.22 |
| CHEMBL440096 | — | — | 1 | 7.96 |
| CHEMBL281338 | — | — | 1 | 7.66 |
| CHEMBL22721 | — | — | 1 | 7.62 |
| CHEMBL277620 | — | — | 1 | 7.60 |
| CHEMBL21513 | — | — | 1 | 7.60 |
| CHEMBL280380 | — | — | 1 | 7.58 |
| CHEMBL21570 | — | — | 1 | 7.30 |
| CHEMBL277619 | — | — | 1 | 6.75 |
| CHEMBL22363 | — | — | 1 | 6.70 |
| CHEMBL2093006 | — | — | 1 | 6.64 |
| CHEMBL2112933 | — | — | 1 | 6.64 |
| CHEMBL21960 | — | — | 1 | 6.60 |
| CHEMBL21392 | — | — | 1 | 6.51 |
| CHEMBL418188 | — | — | 1 | 6.50 |
| CHEMBL281621 | — | — | 1 | 6.42 |
| CHEMBL21072 | — | — | 1 | 6.40 |
| CHEMBL428709 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21954 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL21852 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL21639 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL416374 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL282884 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL21647 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL277689 | SAMIXOGREL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL21303 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL281398 | TERBOGREL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL280728 | RIDOGREL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL21476 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL22023 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL21478 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL440096 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL281338 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL22721 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL21513 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL277620 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL280380 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL21570 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL277619 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL22363 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2093006 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2112933 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL21960 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL21392 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL418188 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL281621 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL21072 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL428709 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL421854 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL7718 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL21874 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL21849 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL21851 | — | IC50 | = | 3900.0 | nM | 5.41 |