Assay Detail
Binding
CHEMBL813722
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In vitro inhibition of Thromboxane A2 synthase in human platelet
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.90 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118944 | — | — | 1 | 6.66 |
| CHEMBL118462 | — | — | 1 | 6.08 |
| CHEMBL555463 | — | — | 1 | 5.60 |
| CHEMBL119841 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118944 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL118462 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL555463 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL119841 | — | IC50 | = | 5800.0 | nM | 5.24 |