Assay Detail
Functional
CHEMBL813724
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Approach to dual-acting platelet activating factor (PAF) receptor antagonist/thromboxane synthase inhibitor (TxSI) based on the link of PAF antagonists and TxSIs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.93 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | 9.05 |
| CHEMBL117233 | — | — | 1 | 9.00 |
| CHEMBL116975 | — | — | 1 | 8.92 |
| CHEMBL117816 | — | — | 1 | 8.74 |
| CHEMBL263227 | — | — | 1 | 8.44 |
| CHEMBL117018 | — | — | 1 | 8.33 |
| CHEMBL2111765 | — | — | 1 | 8.24 |
| CHEMBL324533 | — | — | 1 | 7.92 |
| CHEMBL116673 | — | — | 1 | 7.68 |
| CHEMBL420137 | — | — | 1 | 7.68 |
| CHEMBL11662 | OZAGREL | 4.0 | 1 | 7.62 |
| CHEMBL539177 | — | — | 1 | 7.36 |
| CHEMBL117889 | — | — | 1 | 7.28 |
| CHEMBL323798 | — | — | 1 | 7.19 |
| CHEMBL408135 | — | — | 1 | 7.14 |
| CHEMBL324118 | — | — | 1 | 7.14 |
| CHEMBL114843 | — | — | 1 | 7.06 |
| CHEMBL114251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26820 | (E)-ISBOGREL | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL117233 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL116975 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL117816 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL263227 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL117018 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2111765 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL324533 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL116673 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL420137 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL11662 | OZAGREL | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL539177 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL117889 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL323798 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL408135 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL324118 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL114843 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL114251 | — | IC50 | > | 1000.0 | nM | - |