Assay Detail
Functional
CHEMBL813726
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Inhibition of thromboxane A2 synthetase as reduced ADP-induced aggregation of human platelet rich plasma in the presence of pig aortal microsomes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Aorta |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
[(1H-imidazol-1-yl)methyl]- and [(3-pyridinyl)methyl]pyrroles as thromboxane synthetase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.76 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353950 | — | — | 1 | 7.38 |
| CHEMBL170754 | — | — | 1 | 7.36 |
| CHEMBL352763 | — | — | 1 | 7.30 |
| CHEMBL170776 | — | — | 1 | 6.00 |
| CHEMBL11662 | OZAGREL | 4.0 | 1 | 5.85 |
| CHEMBL169331 | — | — | 1 | 5.80 |
| CHEMBL352512 | — | — | 1 | 5.68 |
| CHEMBL167601 | — | — | 1 | 5.42 |
| CHEMBL352874 | — | — | 1 | 5.34 |
| CHEMBL170615 | — | — | 1 | 5.04 |
| CHEMBL169905 | — | — | 1 | 5.04 |
| CHEMBL354424 | — | — | 1 | 4.62 |
| CHEMBL262055 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353950 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL170754 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL352763 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL170776 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL11662 | OZAGREL | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL169331 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL352512 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL167601 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL352874 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL170615 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL169905 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL354424 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL262055 | — | IC50 | = | 78000.0 | nM | 4.11 |