Assay Detail
Binding
CHEMBL813843
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Inhibitory concentration of compound to inhibit Thymidylate synthase (TS) in L1210 cells at conc. of 200 uM
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.53 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422395 | — | — | 1 | 7.70 |
| CHEMBL22632 | — | — | 1 | 7.22 |
| CHEMBL171480 | — | — | 1 | 6.80 |
| CHEMBL170846 | — | — | 1 | 6.28 |
| CHEMBL89641 | — | — | 1 | 4.64 |
| CHEMBL23977 | DIDEAZAFOLATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422395 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL22632 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL171480 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL170846 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL89641 | — | IC50 | = | 22720.0 | nM | 4.64 |
| CHEMBL23977 | DIDEAZAFOLATE | IC50 | = | 2.44 | — | - |