Assay Detail
Binding
CHEMBL813867
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 3 of male guinea pig lung membrane
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Combined tachykinin receptor antagonist: synthesis and stereochemical structure-activity relationships of novel morpholine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.65 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2115415 | — | — | 1 | 9.14 |
| CHEMBL295615 | — | — | 1 | 8.57 |
| CHEMBL2114963 | — | — | 1 | 7.96 |
| CHEMBL298247 | — | — | 1 | 7.77 |
| CHEMBL2114965 | — | — | 1 | 6.28 |
| CHEMBL2115416 | — | — | 1 | 6.18 |
| CHEMBL295785 | — | — | 1 | - |
| CHEMBL46795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2115415 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL295615 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL2114963 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL298247 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2114965 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2115416 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL295785 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL46795 | — | IC50 | > | 1000.0 | nM | - |