Assay Detail
Binding
CHEMBL814043
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Tested in vitro in rat liver squalene synthase assay (RLSS)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.93 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434998 | — | — | 1 | 9.30 |
| CHEMBL336565 | — | — | 1 | 9.18 |
| CHEMBL134888 | — | — | 1 | 9.06 |
| CHEMBL337391 | — | — | 1 | 8.74 |
| CHEMBL133373 | — | — | 1 | 8.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434998 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL336565 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL134888 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL337391 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL133373 | — | IC50 | = | 4.5 | nM | 8.35 |