Assay Detail
Functional
CHEMBL814154
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Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 1
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.89 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405761 | — | — | 1 | 6.82 |
| CHEMBL53835 | — | — | 1 | 6.00 |
| CHEMBL52562 | — | — | 1 | 5.89 |
| CHEMBL35886 | — | — | 1 | 5.60 |
| CHEMBL65438 | — | — | 1 | 5.52 |
| CHEMBL63910 | — | — | 1 | 5.48 |
| CHEMBL16026 | — | — | 1 | 5.16 |
| CHEMBL296595 | — | — | 1 | 5.10 |
| CHEMBL287727 | — | — | 1 | 5.10 |
| CHEMBL294366 | — | — | 1 | 5.07 |
| CHEMBL65384 | — | — | 1 | 5.00 |
| CHEMBL63463 | — | — | 1 | 4.92 |
| CHEMBL15985 | — | — | 1 | 4.82 |
| CHEMBL65197 | — | — | 1 | 4.70 |
| CHEMBL305113 | — | — | 1 | 4.60 |
| CHEMBL293668 | — | — | 1 | 4.60 |
| CHEMBL64473 | — | — | 1 | 4.52 |
| CHEMBL63439 | — | — | 1 | 4.40 |
| CHEMBL292057 | — | — | 1 | 4.35 |
| CHEMBL36877 | — | — | 1 | 4.30 |
| CHEMBL16193 | — | — | 1 | 4.30 |
| CHEMBL299415 | — | — | 1 | 4.30 |
| CHEMBL64616 | — | — | 1 | 4.26 |
| CHEMBL64766 | — | — | 1 | 4.26 |
| CHEMBL294810 | — | — | 1 | 4.00 |
| CHEMBL51613 | — | — | 1 | 4.00 |
| CHEMBL64298 | — | — | 1 | - |
| CHEMBL53890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405761 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL53835 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL52562 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL35886 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL65438 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL63910 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL16026 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL296595 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL287727 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL294366 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL65384 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL63463 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL15985 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL65197 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL305113 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL293668 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL64473 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL63439 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL292057 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL36877 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL16193 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL299415 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL64616 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL64766 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL294810 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL51613 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL64298 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL53890 | — | IC50 | = | 140000.0 | nM | - |