Assay Detail
Binding
CHEMBL814155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HSV-2 thymidine kinase isolated from HeLa cells
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.33 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405761 | — | — | 1 | 7.00 |
| CHEMBL52562 | — | — | 1 | 6.46 |
| CHEMBL406058 | — | — | 1 | 6.40 |
| CHEMBL406300 | — | — | 1 | 6.22 |
| CHEMBL53835 | — | — | 1 | 6.22 |
| CHEMBL103810 | — | — | 1 | 5.96 |
| CHEMBL103645 | — | — | 1 | 5.92 |
| CHEMBL65438 | — | — | 1 | 5.89 |
| CHEMBL101020 | — | — | 1 | 5.87 |
| CHEMBL102001 | — | — | 1 | 5.82 |
| CHEMBL287727 | — | — | 1 | 5.80 |
| CHEMBL299415 | — | — | 1 | 5.66 |
| CHEMBL296595 | — | — | 1 | 5.60 |
| CHEMBL63463 | — | — | 1 | 5.60 |
| CHEMBL63910 | — | — | 1 | 5.52 |
| CHEMBL35886 | — | — | 1 | 5.40 |
| CHEMBL318027 | — | — | 1 | 5.30 |
| CHEMBL36877 | — | — | 1 | 5.22 |
| CHEMBL16026 | — | — | 1 | 5.10 |
| CHEMBL420269 | — | — | 1 | 5.05 |
| CHEMBL15985 | — | — | 1 | 5.00 |
| CHEMBL63439 | — | — | 1 | 5.00 |
| CHEMBL293668 | — | — | 1 | 4.70 |
| CHEMBL101730 | — | — | 1 | 4.70 |
| CHEMBL53890 | — | — | 1 | 4.70 |
| CHEMBL65197 | — | — | 1 | 4.60 |
| CHEMBL51613 | — | — | 1 | 4.52 |
| CHEMBL64473 | — | — | 1 | 4.40 |
| CHEMBL101651 | — | — | 1 | 4.33 |
| CHEMBL101143 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405761 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL52562 | — | IC50 | = | 346.74 | nM | 6.46 |
| CHEMBL406058 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL406300 | — | IC50 | = | 602.56 | nM | 6.22 |
| CHEMBL53835 | — | IC50 | = | 602.56 | nM | 6.22 |
| CHEMBL103810 | — | IC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL103645 | — | IC50 | = | 1202.26 | nM | 5.92 |
| CHEMBL65438 | — | IC50 | = | 1288.25 | nM | 5.89 |
| CHEMBL101020 | — | IC50 | = | 1348.96 | nM | 5.87 |
| CHEMBL102001 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL287727 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL299415 | — | IC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL296595 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL63463 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL63910 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL35886 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL318027 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL36877 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL16026 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL420269 | — | IC50 | = | 8912.51 | nM | 5.05 |
| CHEMBL15985 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL63439 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL293668 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL101730 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL53890 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL65197 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL51613 | — | IC50 | = | 30199.52 | nM | 4.52 |
| CHEMBL64473 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL101651 | — | IC50 | = | 46773.51 | nM | 4.33 |
| CHEMBL101143 | — | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL16193 | — | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL103978 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL99634 | — | IC50 | = | 199526.23 | nM | - |
| CHEMBL327494 | — | IC50 | = | 251188.64 | nM | - |
| CHEMBL298986 | — | IC50 | = | 257039.58 | nM | - |