Assay Detail
Functional
CHEMBL814285
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Inhibitory activity against U-46,619-induced responses in human platelet aggregation (Thromboxane A2 alpha receptor)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of halogenated trimetoquinol derivatives and evaluation of their beta-agonist and thromboxane A2 (TXA2) antagonist activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.52 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174984 | TRETOQUINOL | 2.0 | 1 | 6.55 |
| CHEMBL2092996 | — | — | 1 | 5.61 |
| CHEMBL1788251 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174984 | TRETOQUINOL | IC50 | = | 281.84 | nM | 6.55 |
| CHEMBL2092996 | — | IC50 | = | 2454.71 | nM | 5.61 |
| CHEMBL1788251 | — | IC50 | = | 39810.72 | nM | 4.40 |