Assay Detail

CHEMBL814312

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Binding

Inhibition of platelet microsomal thromboxane A synthetase in humans

ChEMBL ↗

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Target

Thromboxane-A synthase (CHEMBL1835) ↗

Open DB target context

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Thromboxane-A synthase (CHEMBL1835) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Thromboxane-A synthase

CHEMBL1835

Anchored from Assay target.

Protein identity Thromboxane-A synthase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Thromboxane-A synthase (CHEMBL1835) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Synthesis and thromboxane synthetase inhibitory activity of di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives.

Amemiya Y, Terada A, Wachi K, Miyazawa H, Hatakeyama N, Matsuda K, Oshima T.
J Med Chem (1989) 32 : 1265 -1272
PubMed 2724299 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.21	6.21

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL267473	DAZOXIBEN	2.0	1	6.21

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL267473	DAZOXIBEN	IC50	=	620.0	nM	6.21