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Assay Detail

CHEMBL814316

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The inhibition constant against human thrombin
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tetrahydro-isoquinoline-based factor Xa inhibitors.
Kucznierz R, Grams F, Leinert H, Marzenell K, Engh RA, von der Saal W.
J Med Chem (1998) 41 : 4983 -4994
PubMed 9836616 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 5.01 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL435028 1 5.40
CHEMBL144707 1 5.30
CHEMBL357832 1 5.10
CHEMBL146940 1 5.10
CHEMBL344309 1 4.89
CHEMBL344281 1 4.82
CHEMBL147436 1 4.80
CHEMBL147631 1 4.70
CHEMBL147789 1 -
CHEMBL144079 1 -
CHEMBL147988 1 -
CHEMBL147707 1 -
CHEMBL356973 1 -
CHEMBL358566 1 -
CHEMBL148972 1 -
CHEMBL146097 1 -
CHEMBL144637 1 -
CHEMBL342568 1 -
CHEMBL418849 1 -
CHEMBL539053 DX-9065A HYDROCHLORIDE HYDRATE 1 -
CHEMBL148357 1 -
CHEMBL439982 1 -
CHEMBL344305 1 -
CHEMBL148323 1 -
CHEMBL148343 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL435028 Ki = 4000.0 nM 5.40
CHEMBL144707 Ki = 5000.0 nM 5.30
CHEMBL357832 Ki = 8000.0 nM 5.10
CHEMBL146940 Ki = 8000.0 nM 5.10
CHEMBL344309 Ki = 13000.0 nM 4.89
CHEMBL344281 Ki = 15000.0 nM 4.82
CHEMBL147436 Ki = 16000.0 nM 4.80
CHEMBL147631 Ki = 20000.0 nM 4.70
CHEMBL147789 Ki > 100000.0 nM -
CHEMBL144079 Ki > 100000.0 nM -
CHEMBL147988 Ki > 100000.0 nM -
CHEMBL147707 Ki > 100000.0 nM -
CHEMBL356973 Ki > 100000.0 nM -
CHEMBL358566 Ki > 100000.0 nM -
CHEMBL148972 Ki > 100000.0 nM -
CHEMBL146097 Ki > 100000.0 nM -
CHEMBL144637 Ki > 100000.0 nM -
CHEMBL342568 Ki > 100000.0 nM -
CHEMBL418849 Ki > 100000.0 nM -
CHEMBL539053 DX-9065A HYDROCHLORIDE HYDRATE Ki > 100000.0 nM -
CHEMBL148357 Ki > 100000.0 nM -
CHEMBL439982 Ki > 100000.0 nM -
CHEMBL344305 Ki > 100000.0 nM -
CHEMBL148323 Ki > 100000.0 nM -
CHEMBL148343 Ki > 100000.0 nM -