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Assay Detail

CHEMBL814332

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Binding
Compound was evaluated for inhibition of Microbial tyramine oxidase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Fluorinated phenylcyclopropylamines. 1. Synthesis and effect of fluorine substitution at the cyclopropane ring on inhibition of microbial tyramine oxidase.
Yoshida S, Meyer OG, Rosen TC, Haufe G, Ye S, Sloan MJ, Kirk KL.
J Med Chem (2004) 47 : 1796 -1806
PubMed 15027872 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 6.83 7.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL500093 1 7.48
CHEMBL51601 1 6.18
CHEMBL903 HYDRAZINECARBOXAMIDE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL500093 IC50 = 33.0 nM 7.48
CHEMBL51601 IC50 = 660.0 nM 6.18
CHEMBL903 HYDRAZINECARBOXAMIDE IC50 = 6.7 nM -