Compound Detail
CHEMBL500093
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Basic Information
| ChEMBL ID | CHEMBL500093 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IQFBVCYZPKNMIN-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1187354 |
| Active Moiety | CHEMBL1187354 |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
147.2
MW (Da)
1.75
ALogP
1
HBA
1
HBD
26.0
PSA (Ų)
0.68
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 7.89
IC50 1 meas. best 7.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C CHEMBL225 | EC50 | 7.89 | 7.89 | 13.0 | 1 |
| Amine oxidase [flavin-containing] B CHEMBL2039 | IC50 | 7.48 | 7.48 | 33.0 | 1 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | EC50 | 7.07 | 7.07 | 85.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | EC50 | 5.85 | 5.85 | 1399.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | EC50 | = | 13.0 | nM | 7.89 | Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as c... | 19284718 |
| Amine oxidase [flavin-containing] B | IC50 | = | 33.0 | nM | 7.48 | Compound was evaluated for inhibition of Microbial tyramine oxidase | 15027872 |
| 5-hydroxytryptamine receptor 2B | EC50 | = | 85.0 | nM | 7.07 | Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as c... | 19284718 |
| 5-hydroxytryptamine receptor 2A | EC50 | = | 1399.0 | nM | 5.85 | Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as c... | 19284718 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19284718 | 10.1021/jm801354e | 5-hydroxytryptamine receptor 2A | 2 |
| 19284718 | 10.1021/jm801354e | 5-hydroxytryptamine receptor 2B | 2 |
| 19284718 | 10.1021/jm801354e | 5-hydroxytryptamine receptor 2C | 2 |
| 15027872 | 10.1021/jm030398k | Amine oxidase [flavin-containing] B | 1 |
| 19284718 | 10.1021/jm801354e | Serotonin 2 receptors; 5-HT2a & 5-HT2c | 1 |
| 19284718 | 10.1021/jm801354e | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine