Assay Detail
Functional
CHEMBL957592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
72
Total Activities
72
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 50 | 7.12 | 9.30 |
| Activity | 22 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 9.30 |
| CHEMBL492926 | — | — | 1 | 8.44 |
| CHEMBL492916 | — | — | 1 | 8.32 |
| CHEMBL474633 | — | — | 1 | 8.31 |
| CHEMBL510383 | — | — | 1 | 8.26 |
| CHEMBL474634 | — | — | 1 | 8.15 |
| CHEMBL475642 | — | — | 1 | 8.08 |
| CHEMBL475643 | — | — | 1 | 7.92 |
| CHEMBL467736 | — | — | 1 | 7.89 |
| CHEMBL464475 | — | — | 1 | 7.85 |
| CHEMBL493130 | — | — | 1 | 7.68 |
| CHEMBL451232 | — | — | 1 | 7.66 |
| CHEMBL492306 | — | — | 1 | 7.55 |
| CHEMBL443128 | — | — | 1 | 7.50 |
| CHEMBL452719 | — | — | 1 | 7.43 |
| CHEMBL471202 | — | — | 1 | 7.43 |
| CHEMBL450599 | — | — | 1 | 7.28 |
| CHEMBL493128 | — | — | 1 | 7.23 |
| CHEMBL445747 | — | — | 1 | 7.19 |
| CHEMBL510308 | — | — | 1 | 7.16 |
| CHEMBL493129 | — | — | 1 | 7.12 |
| CHEMBL490064 | — | — | 1 | 7.11 |
| CHEMBL452458 | — | — | 1 | 7.08 |
| CHEMBL500093 | — | — | 1 | 7.07 |
| CHEMBL475641 | — | — | 1 | 6.94 |
| CHEMBL508680 | — | — | 1 | 6.94 |
| CHEMBL506727 | — | — | 1 | 6.85 |
| CHEMBL450178 | — | — | 1 | 6.73 |
| CHEMBL451368 | — | — | 1 | 6.70 |
| CHEMBL474230 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL492926 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL492916 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL474633 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL510383 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL474634 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL475642 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL475643 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL467736 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL464475 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL493130 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL451232 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL492306 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL443128 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL471202 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL452719 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL450599 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL493128 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL445747 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL510308 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL493129 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL490064 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL452458 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL500093 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL508680 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL475641 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL506727 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL450178 | — | EC50 | = | 185.0 | nM | 6.73 |
| CHEMBL451368 | — | EC50 | = | 199.0 | nM | 6.70 |
| CHEMBL474230 | — | EC50 | = | 204.0 | nM | 6.69 |
| CHEMBL360328 | LORCASERIN | EC50 | = | 219.0 | nM | 6.66 |
| CHEMBL509418 | — | EC50 | = | 224.0 | nM | 6.65 |
| CHEMBL492917 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL492305 | — | EC50 | = | 366.0 | nM | 6.44 |
| CHEMBL469729 | — | EC50 | = | 404.0 | nM | 6.39 |
| CHEMBL471802 | — | EC50 | = | 415.0 | nM | 6.38 |
| CHEMBL501526 | — | EC50 | = | 459.0 | nM | 6.34 |
| CHEMBL501117 | — | EC50 | = | 492.0 | nM | 6.31 |
| CHEMBL474885 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL472678 | — | EC50 | = | 1739.0 | nM | 5.76 |
| CHEMBL501854 | — | EC50 | = | 2737.0 | nM | 5.56 |
| CHEMBL449134 | — | EC50 | = | 3092.0 | nM | 5.51 |
| CHEMBL498863 | — | EC50 | = | 3342.0 | nM | 5.48 |
| CHEMBL474950 | — | Activity | - | — | - | |
| CHEMBL492698 | — | Activity | - | — | - | |
| CHEMBL474232 | — | Activity | - | — | - | |
| CHEMBL474231 | — | Activity | - | — | - | |
| CHEMBL474229 | — | Activity | - | — | - | |
| CHEMBL469808 | — | Activity | - | — | - | |
| CHEMBL475383 | — | Activity | - | — | - |