Assay Detail
Binding
CHEMBL814386
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In vitro for inhibitory activity against thromboxane synthase
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.63 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151083 | — | — | 1 | 8.59 |
| CHEMBL151091 | — | — | 1 | 8.57 |
| CHEMBL151519 | — | — | 2 | 8.23 |
| CHEMBL150563 | — | — | 1 | 8.03 |
| CHEMBL150206 | — | — | 1 | 7.94 |
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 7.83 |
| CHEMBL57576 | — | — | 1 | 7.61 |
| CHEMBL60710 | — | — | 1 | 7.60 |
| CHEMBL357723 | — | — | 1 | 7.54 |
| CHEMBL291539 | — | — | 1 | 7.51 |
| CHEMBL150289 | — | — | 1 | 7.48 |
| CHEMBL147444 | — | — | 1 | 7.45 |
| CHEMBL346644 | — | — | 1 | 7.43 |
| CHEMBL347343 | — | — | 1 | 7.38 |
| CHEMBL151860 | — | — | 1 | 7.32 |
| CHEMBL150436 | — | — | 1 | 7.31 |
| CHEMBL150252 | — | — | 1 | 7.31 |
| CHEMBL150660 | — | — | 1 | 7.31 |
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | 7.31 |
| CHEMBL424139 | — | — | 1 | 7.29 |
| CHEMBL299467 | — | — | 1 | 7.26 |
| CHEMBL147308 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151083 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL151091 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL151519 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL151519 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL150563 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL150206 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL280728 | RIDOGREL | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL57576 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL60710 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL357723 | — | IC50 | = | 28.7 | nM | 7.54 |
| CHEMBL291539 | — | IC50 | = | 31.2 | nM | 7.51 |
| CHEMBL150289 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL147444 | — | IC50 | = | 35.7 | nM | 7.45 |
| CHEMBL346644 | — | IC50 | = | 36.7 | nM | 7.43 |
| CHEMBL347343 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL151860 | — | IC50 | = | 47.5 | nM | 7.32 |
| CHEMBL150436 | — | IC50 | = | 49.2 | nM | 7.31 |
| CHEMBL150660 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL150252 | — | IC50 | = | 48.9 | nM | 7.31 |
| CHEMBL26820 | (E)-ISBOGREL | IC50 | = | 48.7 | nM | 7.31 |
| CHEMBL424139 | — | IC50 | = | 50.8 | nM | 7.29 |
| CHEMBL299467 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL147308 | — | IC50 | = | 63.0 | nM | 7.20 |