Assay Detail
Binding
CHEMBL814409
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Inhibition of Thromboxane-A synthase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.50 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267473 | DAZOXIBEN | 2.0 | 1 | 5.96 |
| CHEMBL299186 | — | — | 1 | 5.80 |
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267473 | DAZOXIBEN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL299186 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL488 | AMINOGLUTETHIMIDE | IC50 | = | 18500.0 | nM | 4.73 |