Assay Detail
Functional
CHEMBL814436
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Tested for antagonistic activity on isolated rat thoracic aorta (thromboxane A2 receptor) precontracted by U-46619 (3 x 10 e-8 M)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Thoracic aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Role of sulfonamide moiety in non-prostanoid txa2 receptor antagonist kt2-962 : modifications of this moiety and the resulting activities
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.63 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262655 | — | — | 1 | 9.05 |
| CHEMBL298462 | — | — | 1 | 6.66 |
| CHEMBL46338 | — | — | 1 | 6.07 |
| CHEMBL430569 | — | — | 1 | 6.07 |
| CHEMBL47605 | — | — | 1 | 5.85 |
| CHEMBL297275 | — | — | 1 | 5.82 |
| CHEMBL8273 | SULOTROBAN | 2.0 | 1 | 5.82 |
| CHEMBL48013 | — | — | 1 | 5.82 |
| CHEMBL47743 | — | — | 1 | 5.77 |
| CHEMBL297808 | — | — | 1 | 5.58 |
| CHEMBL47510 | — | — | 1 | 5.06 |
| CHEMBL43726 | — | — | 1 | 5.06 |
| CHEMBL47658 | — | — | 1 | 5.04 |
| CHEMBL48117 | — | — | 1 | 4.92 |
| CHEMBL45471 | — | — | 1 | 4.72 |
| CHEMBL297989 | — | — | 1 | 4.27 |
| CHEMBL45623 | — | — | 1 | 4.19 |
| CHEMBL47635 | — | — | 1 | - |
| CHEMBL296652 | — | — | 1 | - |
| CHEMBL43880 | — | — | 1 | - |
| CHEMBL45360 | — | — | 1 | - |
| CHEMBL44769 | — | — | 1 | - |
| CHEMBL413055 | — | — | 1 | - |
| CHEMBL297315 | — | — | 1 | - |
| CHEMBL296727 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262655 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL298462 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL46338 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL430569 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL47605 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL297275 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL8273 | SULOTROBAN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL48013 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL47743 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL297808 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL47510 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL43726 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL47658 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL48117 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL45471 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL297989 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL45623 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL47635 | — | IC50 | = | 590000.0 | nM | - |
| CHEMBL296652 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL43880 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL45360 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44769 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL413055 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL297315 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL296727 | — | IC50 | > | 100000.0 | nM | - |