Assay Detail
Functional
CHEMBL814439
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In vitro Thromboxane receptor antagonist against U-46619 induced contraction of dog saphenous vein
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Tissue | Saphenous vein |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Oxa-prostanoid analogs. Identification of an orally effective, dual thromboxane receptor antagonist /thromboxane synthase inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.53 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65414 | — | — | 1 | 8.90 |
| CHEMBL63040 | — | — | 3 | 7.98 |
| CHEMBL302457 | — | — | 1 | 7.13 |
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65414 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL63040 | — | Kd | = | 10.47 | nM | 7.98 |
| CHEMBL63040 | — | Kd | = | 21.88 | nM | 7.66 |
| CHEMBL63040 | — | Kd | = | 70.79 | nM | 7.15 |
| CHEMBL302457 | — | Kd | = | 74.13 | nM | 7.13 |
| CHEMBL280728 | RIDOGREL | Kd | = | 446.68 | nM | 6.35 |