Assay Detail
Binding
CHEMBL814593
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Binding affinity towards thyroid hormone receptor (hTR alpha 1)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A designed antagonist of the thyroid hormone receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.90 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 9.77 |
| CHEMBL318132 | — | — | 1 | 6.95 |
| CHEMBL264527 | — | — | 1 | 6.62 |
| CHEMBL97613 | — | — | 1 | 6.37 |
| CHEMBL97187 | — | — | 1 | 5.85 |
| CHEMBL98135 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | Kd | = | 0.17 | nM | 9.77 |
| CHEMBL318132 | — | Kd | = | 112.0 | nM | 6.95 |
| CHEMBL264527 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL97613 | — | Kd | = | 430.0 | nM | 6.37 |
| CHEMBL97187 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL98135 | — | Kd | = | 1400.0 | nM | 5.85 |