Assay Detail
Binding
CHEMBL814596
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Concentration required to inhibit 50% of binding of [125I]-T3 to human Thyroid hormone receptor alpha-1 in CHO-K1 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.87 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL633 | AMIODARONE | 4.0 | 1 | 6.19 |
| CHEMBL160883 | — | — | 1 | 6.09 |
| CHEMBL160703 | — | — | 1 | 5.85 |
| CHEMBL157885 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL633 | AMIODARONE | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL160883 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL160703 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL157885 | — | IC50 | = | 4500.0 | nM | 5.35 |