Assay Detail
Binding
CHEMBL814615
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Inhibition of tyrosine protein kinase receptor TIE-2 with 1 mM ATP and biotinylated lck peptide
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.90 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47787 | — | — | 1 | 6.28 |
| CHEMBL431609 | — | — | 1 | 6.28 |
| CHEMBL431407 | — | — | 1 | 5.99 |
| CHEMBL43773 | — | — | 1 | 5.95 |
| CHEMBL314627 | — | — | 1 | 5.83 |
| CHEMBL295601 | — | — | 1 | 5.61 |
| CHEMBL297363 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47787 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL431609 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL431407 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL43773 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL314627 | — | IC50 | = | 1484.0 | nM | 5.83 |
| CHEMBL295601 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL297363 | — | IC50 | = | 4680.0 | nM | 5.33 |