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Assay Detail

CHEMBL814654

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Binding
Compound was tested for inhibition of Thymidylate Synthase in Lactobacillus casei,
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Lacticaseibacillus casei
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Thymidylate synthase (CHEMBL5328)
Type SINGLE PROTEIN
Organism Lactobacillus casei

Publication

Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase.
Pogolotti AL, Danenberg PV, Santi DV.
J Med Chem (1986) 29 : 478 -482
PubMed 3754285 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.00 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL389051 1 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL389051 Ki = 10.0 nM 8.00