Assay Detail
Binding
CHEMBL814725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of the high affinity radiolabeled ligand [3H]- SQ-29548 from the PGH-2/TXA-2 receptor in human gel-filtered platelets.
52
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 7.03 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65414 | — | — | 1 | 8.22 |
| CHEMBL338420 | — | — | 1 | 8.05 |
| CHEMBL340504 | — | — | 1 | 7.92 |
| CHEMBL126185 | — | — | 1 | 7.92 |
| CHEMBL127380 | — | — | 1 | 7.92 |
| CHEMBL126577 | — | — | 1 | 7.89 |
| CHEMBL277689 | SAMIXOGREL | 2.0 | 1 | 7.72 |
| CHEMBL127017 | — | — | 1 | 7.72 |
| CHEMBL127683 | — | — | 1 | 7.68 |
| CHEMBL129355 | — | — | 1 | 7.60 |
| CHEMBL126494 | — | — | 1 | 7.58 |
| CHEMBL127008 | — | — | 1 | 7.55 |
| CHEMBL338360 | — | — | 1 | 7.55 |
| CHEMBL129734 | — | — | 1 | 7.48 |
| CHEMBL130470 | — | — | 1 | 7.48 |
| CHEMBL126337 | — | — | 1 | 7.44 |
| CHEMBL338588 | — | — | 1 | 7.38 |
| CHEMBL419774 | — | — | 1 | 7.38 |
| CHEMBL126196 | — | — | 1 | 7.31 |
| CHEMBL419790 | — | — | 1 | 7.29 |
| CHEMBL338241 | — | — | 1 | 7.28 |
| CHEMBL340396 | — | — | 1 | 7.26 |
| CHEMBL338419 | — | — | 1 | 7.24 |
| CHEMBL128022 | — | — | 1 | 7.22 |
| CHEMBL129000 | — | — | 1 | 7.21 |
| CHEMBL127738 | — | — | 1 | 7.21 |
| CHEMBL341094 | — | — | 1 | 7.18 |
| CHEMBL126373 | — | — | 1 | 7.13 |
| CHEMBL126761 | — | — | 1 | 7.09 |
| CHEMBL339269 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65414 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL338420 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL340504 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL127380 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL126185 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL126577 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL277689 | SAMIXOGREL | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL127017 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL127683 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL129355 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL126494 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL127008 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL338360 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL129734 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL130470 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL126337 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL338588 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL419774 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL126196 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL419790 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL338241 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL340396 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL338419 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL128022 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL129000 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL127738 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL341094 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL126373 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL126761 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL339269 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL127212 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL126334 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL129365 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL126333 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL129030 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL127682 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL128104 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL339335 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL339812 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL127357 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL339568 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL127681 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL338546 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL129635 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL125519 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL128678 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL415519 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL338334 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL126654 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL280728 | RIDOGREL | IC50 | = | 1700.0 | nM | 5.77 |