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Assay Detail

CHEMBL814733

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Dissociation constant was determined from radioligand binding studies in human platelet membranes using Thromboxane A2 receptor radioligand [3H]-SQ 29,548.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Thromboxane A2 receptor (CHEMBL2069)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Interphenylene phenyl oxazoles: novel, potent thromboxane receptor antagonists
Misra RN, Harris DN, Michel IM, Goldenberg HJ, Webb ML, Brown BR
Bioorg Med Chem Lett (1992) 2 : 937 -940
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 8.86 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL31765 1 10.00
CHEMBL170747 1 7.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL31765 Kd = 0.1 nM 10.00
CHEMBL170747 Kd = 19.0 nM 7.72