Assay Detail
Functional
CHEMBL814738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Thromboxane (TXA2) receptor antagonist activity using human platelet
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of dual-acting thromboxane antagonist-synthase inhibitors by a mutual prodrug approach
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 5.77 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30024 | — | — | 1 | 8.50 |
| CHEMBL440321 | — | — | 1 | 8.30 |
| CHEMBL96727 | — | — | 1 | 5.90 |
| CHEMBL94692 | — | — | 1 | 5.00 |
| CHEMBL320682 | — | — | 2 | 5.00 |
| CHEMBL327992 | — | — | 1 | 5.00 |
| CHEMBL94375 | — | — | 1 | 5.00 |
| CHEMBL320461 | — | — | 1 | 5.00 |
| CHEMBL94381 | — | — | 1 | 5.00 |
| CHEMBL262223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30024 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL440321 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL96727 | — | Kd | = | 1258.93 | nM | 5.90 |
| CHEMBL94692 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL320682 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL327992 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL94375 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL320682 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL320461 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL94381 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL262223 | — | Kd | > | 10000.0 | nM | - |