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Assay Detail

CHEMBL814739

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619 induced platelet aggregation in human whole blood
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Tissue Blood
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Thromboxane A2 receptor (CHEMBL2069)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and pharmacological evaluation of combined thromboxane receptor antagonist/synthase inhibitors: pyridine-containing sulphonamido acids
Campbell I, Collington E, Finch H, Hayes R, Lumley P, Mills K, Pike N, Robertson G, Watts I
Bioorg Med Chem Lett (1991) 1 : 699 -704
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 17 6.05 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL161253 1 7.00
CHEMBL159775 1 6.70
CHEMBL162641 1 6.70
CHEMBL159979 1 6.50
CHEMBL159936 1 6.50
CHEMBL348790 1 6.20
CHEMBL162879 1 6.20
CHEMBL159447 1 6.10
CHEMBL161422 1 6.10
CHEMBL351657 1 6.10
CHEMBL422017 1 6.00
CHEMBL164109 1 6.00
CHEMBL163276 1 5.80
CHEMBL159481 1 5.70
CHEMBL280728 RIDOGREL 2.0 1 5.40
CHEMBL347812 1 5.10
CHEMBL26820 (E)-ISBOGREL 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL161253 Kd = 100.0 nM 7.00
CHEMBL159775 Kd = 199.53 nM 6.70
CHEMBL162641 Kd = 199.53 nM 6.70
CHEMBL159979 Kd = 316.23 nM 6.50
CHEMBL159936 Kd = 316.23 nM 6.50
CHEMBL348790 Kd = 630.96 nM 6.20
CHEMBL162879 Kd = 630.96 nM 6.20
CHEMBL159447 Kd = 794.33 nM 6.10
CHEMBL161422 Kd = 794.33 nM 6.10
CHEMBL351657 Kd = 794.33 nM 6.10
CHEMBL422017 Kd = 1000.0 nM 6.00
CHEMBL164109 Kd = 1000.0 nM 6.00
CHEMBL163276 Kd = 1584.89 nM 5.80
CHEMBL159481 Kd = 1995.26 nM 5.70
CHEMBL280728 RIDOGREL Kd = 3981.07 nM 5.40
CHEMBL347812 Kd = 7943.28 nM 5.10
CHEMBL26820 (E)-ISBOGREL Kd = 15848.93 nM 4.80